Table 1.
In silico toxicity of 3-aminothiophene-2-carbohydrazide derivatives 5a–i calculated using Osiris program [24,25].
| Compound | Theoretical Toxicity Risks * | |||
|---|---|---|---|---|
| Mutagenic | Tumorigenic | Irritant | Reproductive Effects | |
| Dipyrone | 3 | 3 | 1 | 3 |
| Dexamethasone | 1 | 1 | 1 | 1 |
| Indomethacin | 1 | 1 | 1 | 1 |
| 5a | 1 | 1 | 1 | 1 |
| 5b | 1 | 1 | 3 | 1 |
| 5c | 1 | 1 | 1 | 1 |
| 5d | 1 | 1 | 1 | 1 |
| 5e | 1 | 1 | 2 | 2 |
| 5f | 1 | 3 | 1 | 1 |
| 5g | 1 | 1 | 1 | 1 |
| 5h | 3 | 1 | 1 | 1 |
| 5i | 1 | 1 | 1 | 1 |
* Theoretical toxicity risks calculated using Osiris program. The scale of side effects is low (1), medium (2), and high (3) toxicity profile.