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. 2014 May 6;19(5):5790–5805. doi: 10.3390/molecules19055790

Figure 5.

Figure 5

Neuromuscular responses of indirectly stimulated PND incubated with B. jararacussu venom (40 μg/mL) for 120 min (A). Notice the irreversible blockade. Venom was added at the arrow. Bar = tension of 5 g/cm. W = wash. Panel (B)—Cross-section of diaphragm muscle incubated with venom alone (40 μg/mL, n = 6). Note the edema and intense myonecrosis (muscle fiber atrophy, hyaline aspect, sarcolemmal disruption and myofibril lysis). Panel (C)—Cross-section of diaphragm muscle incubated with a mixture of TM (200 μg/mL) + venom (40 μg/mL). Note the normal appearance of the fibers (polygonal aspect and peripheral nuclei), but with occasional edema. Bar = 50 μm for B and C.