Table 1.

Antiproliferative activity of the artemisinin-indoloquinoline hybrids against human leukemia MV4-11 cell line.

Compound	R1	R2	R3	MV4-11 a IC50 (μM)
cisplatin				2.820 ± 0.450
doxorubicin HCl				0.006 ± 0.002
7a	H	H	H	0.286 ± 0.079
7b	Cl	CH3	CH3	0.072 ± 0.022
7c	Br	CH3	CH3	0.242 ± 0.031
7d	CO2Me	H	H	0.148 ± 0.015
7e	CO2Me	CH3	CH3	0.075 ± 0.001
7f	CO2Me	H	OH	0.226 ± 0.019
8				0.286 ± 0.127
4a b	H	H	H	0.066 ± 0.023
4d c	CO2Me	H	H	0.086 ± 0.020
6 d				0.124 ± 0.010

^a MV4-11, human leukemia cell line; ^b Reference [50]; ^c Reference [51]; ^d Activity against MV4-11 of the compound 9 derived from 6 and artesunate 3 is cited in Reference [54].