Table 13.
Summary of results by compound
| Compound | Longevity reduction (%) | Trehalase activities | β-glucosidase activities | Quantification sugar ingested (ηl) | Anti-Leishmania | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Males | Females | Males | Females | Males | Females | Males | Females | Culture | Infection | |
| Amygdalin | ne | 13 | nt | nt | nt | nt | nt | nt | ne | nt |
| Esculin | 12 | 13 | ne | RBT/RBS inhibition (ivt) | ne | RBS activation (ivv) | 20.4 ± 1.9 | 13.1 ± 1.5 | ne | nt |
| Mandelonitrile | 59 | 33 | nt | nt | nt | nt | nt | nt | Yes, all species tested | nt |
| Esculetin | -29 | ne | GC inhibition (ivt) | RBT inhibition (ivt) | ne | RBS activation (ivt) | 19 ± 3 | 26 ± 3 | Yes, L. infantum/L. mexicana | Yes, L. mexicana |
Abbreviations: ivt in vitro, ivv in vivo, nt not tested, ne no effect, GT gut tissue, GC gut contents, RBT rest of the body tissues, RBS rest of the body soluble fraction