Table 2.
Anti-HCV activity of compounds 7a–i.
| Compound | CC50 (µM) a | IC50 (µM) b | SI c |
|---|---|---|---|
| 7a | ≥50 µM | >10 | 5 |
| 7b | ≥100 µM | >10 | 10 |
| 7c | ≥50 µM | >10 | 5 |
| 7d | ≥100 µM | >10 | 10 |
| 7e | ≥50 µM | >10 | 5 |
| 7f | ≥50 µM | >10 | 5 |
| 7g | ≥100 µM | >10 | 10 |
| 7h | ≥50 µM | >10 | 5 |
| 7i | ≥50 µM | >10 | 5 |
| 2CmeCyt | >300 | 1.5 | 200 |
| aIFNB2 | >10,000 d | 1.5 d | 6667 |
a CC50 Concentrations of compound required for 50% extinction of Huh 5.2 cells; b IC50 Concentrations of compound achieving 50% inhibition of the replicon system; c SI selectivity index = CC50/IC50; d interferon reported as IU/mL.