. 2014 Aug 5;19(8):11586–11599. doi: 10.3390/molecules190811586

Table 4.

Correlation analysis between miRNAs and clinicopathological features.

Clinical Features	Group	n	miR-30a-3p		miR-146b-5p		miR-199b-5p
Clinical Features	Group	n	Expression Level	p	Expression Level	p	Expression Level	p
Age	≥45	21	−2.56 (−3.32–−1.27)	0.547	3.44 (0.97–3.69)	0.705	−2.54 (−3.39–−1.92)	0.319 *
Age	˂45	15	−1.54 (−4.39–−0.27)	0.547	1.94 (0.97–4.97)	0.705	−1.81 (−3.67–−0.13)	0.319 *
Sex	Male	7	−1.73 (−3.62–0.60)	0.670	3.62 (1.12–6.12)	0.279	−0.56 (−2.84–0.17)	0.092 *
Sex	Female	29	−2.099 (−3.69–−0.84)	0.670	2.61 (0.16–4.08)	0.279	−2.54 (−3.85–−1.33)	0.092 *
Tumor size	≤1 cm	14	−1.61 (−3.88–0.33)	0.482	3.57 (1.05–4.97)	0.352	−1.63 (−2.97–0.11)	0.125 *
Tumor size	˃1 cm	22	−2.329 (−3.50–−1.26)	0.482	2.51 (−1.4–4.06)	0.352	−2.67 (−5.28–−1.73)	0.125 *
Number of foci	Single lesion	20	−1.97 (−3.17–−1.23)	0.058	3.84 (2.36–5.21)	0.339	−1.38 (−3.18–0.17)	0.650 *
Number of foci	Multiple lesions	16	−3.60 (−4.72–−2.93)	0.058	3.47 (1.15–4.33)	0.339	−1.98 (−2.71–−1.22)	0.650 *
Extrathyroidal extension	NO	27	−2.93 (−4.56–−1.56)	0.435	3.69 (1.15–5.10)	0.678	−2.51 (−2.97–−1.29)	0.047 *
Extrathyroidal extension	YES	9	−1.97 (−3.52–−1.47)	0.435	3.73 (3.05–3.96)	0.678	0.21 (−1.80–0.44)	0.047 *
Lymph node metastasis	N₀	15	−3.15 (−3.88–−1.56)	0.679	3.63 (1.15–4.06)	0.303	−2.54 (−3.39–−1.92)	0.010 ^#
	N_1a	9	−2.37 (−3.60–−1.97)		3.80 (3.47–5.45)		–2.61 (−3.65–−1.22)
	N_1b	12	−1.65 (−4.56–0.87)		4.97 (1.27–5.75)		0.10 (−0.62–0.29)

The expression values were calculated by (−∆∆CT) miRNA expression levels are presented as the median and interquartile AJCC TNM staging the seventh edition [19]. * Using the Mann-Whitney U test, ^# Using the Kruskal-Wallis H test.