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Effect of luteolin on compound 48/80-induced scratching behavior (A) and vascular permeability (B) in mice. Scratching behavior was counted for 60 min after intradermal injection of compound 48/80 (50 μg/site). Luteolin (1–20 mg/kg) was orally administered 1 h before injection of compound 48/80. Values are means ± standard error (SE) (n = 8). # p < 0.001 versus the non-treated control group; * p < 0.05, ** p < 0.05, *** p < 0.01 versus compound 48/80 alone group.
