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Effects of cudraflavone B-induced Nrf2-mediated HO-1 expression on glutamate-induced oxidative neurotoxicity (A) and ROS generation (B) in HT22 cells. HT22 cells were treated with 40 μM of cudraflavone B in the presence or absence of 50 μM SnPP IX and Nrf2 siRNA, after then exposed to glutamate (5 mM) for 12 h (A, B). Data are presented as the mean ± SD values of three independent experiments. Trolox was used as the positive control. * p < 0.05.
