Table 1.

Clinical trials reported to test the preventive efficacy of artemether against S. japonicum infection.

Treatment Regimen	Preventive Efficacy (%)	Endemic Type of the Pilot	Adverse Events	Reference
Four doses of artemether (6 mg/kg) given once every 15 days	60.8	Islet with embankment	None	[50]
Four doses of artemether (6 mg/kg) given once every 15 days	71.7	Mountainous region	6 cases developed mild, transient dizziness, nausea, abdominal pain and diarrhea after the first treatment	[51]
Ten doses of artemether (6 mg/kg) given once every 15 days	75.9	Mountainous region	Mild, transient dizziness (0.67%), burning sensation in the upper abdomen (0.45%), abdominal pain (0.38%), fever (0.18%), abdominal distension (0.11%), vomiting (0.41%), abdominal pain (0.23%), diarrhea (0.13%), and palpitation (0.07%)	[52]
Nine doses of artemether (6 mg/kg) given once every 15 days	94	Islet with embankment	None	[53]
Ten doses of artemether (6 mg/kg) given once every 15 days	100	Marshland region	None	[54]
Two doses of artemether (6 mg/kg) given 15 days apart, with an additional dose 15 days post-exposure	91	Marshland region	None	[55]
Nine to eleven doses of artemether (6 mg/kg) given once every two weeks	94.6	Lake region	None	[56]
Eleven doses of artemether (6 mg/kg) given once every 15 days	94.47	Marshland region	Transient dizziness (0.65%), burning sensation in the upper abdomen (0.45%), abdominal pain (0.38%), fever (0.18%), abdominal distension (0.11%) and vomiting (0.09%),	[57]