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Synthesis of solid support 4 and phosphoramidite 12 used for the preparation of 3'-and 5'-TA oligonucleotides TA_I, TA_II and 5'TA_I, respectively.
Reagents and conditions: (i) Thioctic acid, EDCI, HOBt, DIEA, DMF; (ii) dimethoxytrityl chloride, pyr; (iii) succinic anhydride, DMAP, pyr; LCAA CPG (long chain aminoalkyl controlled pore glass), TBTU, TEA, ACN; (v) 2-cyanoethyl-N,N-diisopropylaminohlorophosphine, DIEA, DCM.
