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Synthesis of the solid supports needed for the preparation of 3'-TA- terminated oligonucleotides TA_III(a), TA_III(b) and TA_III(c).
Reagents and conditions: (i) Carboxylic acids III(a)-III(c) or thioctic acid, DCC, p-nitrophenol, pyr.; (ii) 5a–5c, DMF; (iii) TFA 10% DCM; (iv) 6, DMF. (v) dimethoxytrityl chloride, pyr.; (vi) succinic anhydride, DMAP, pyr.; (vii) LCAA CPG (long chain aminoalkyl controlled pore glass), TBTU, TEA, ACN.
