Table 1.
Effects of Km, FLX, DMI, and IMI on open field test activity.
Treatment (mg/kg) | Ambulatory Activity (Count Number/5 min) | Rearing Number/5 min |
---|---|---|
Control | 31.7 ± 3.24 | 17.6 ± 1.46 |
Km1 | 35.0 ± 3.31 | 13.0 ± 3.40 |
Km5 | 29.0 ± 3.48 | 20.5 ± 3.90 |
Km10 | 32.1 ± 3.64 | 13.8 ±3.23 |
Km20 | 44.7 ± 0.2.29 * | 17.7 ± 2.80 |
H = 10.72, df = 4, p = 0.030 | H = 3.18, df = 4, p = 0.527 | |
Control | 41. 12 ±1.32 | 25.25 ± 3.63 |
FLX10 | 37.00 ± 2.17 | 21.75 ± 3.37 |
FLX 15 | 45.37 ± 3.13 | 28.12 ± 0.81 |
H = 5.39, df = 2, p = 0.067 | H = 3.56, df = 2, p = 0.168 | |
Control DMI 3.12 DMI 6.25 | 37.7 ± 3.24 35.50 ± 5.58 40.5 ± 6.33 | 29.3 ± 5.73 26.53 ± 3.82 26.8 ± 4.20 |
DMI 12.5 | 47.8 ± 3.92 | 28.0 ± 3.53 |
DMI25 | 40.1 ± 4.76 | 18.7 ± 5.26 |
H = 6.08, df = 4, p = 0.193 | H = 4.97, df = 4, p = 0.06 | |
Control | 38.8 ± 1.29 | 25.2 ± 3.63 |
IMI 6.25 | 44.5 ± 6.04 | 36.5 ± 4.67 |
12.5 | 30.2 ± 4.43 | 27.5 ± 2.77 |
25 | 41.12 ± 6.18 | 34.5 ±7.72 |
H = 3.508, df = 3, p = 0.320 | H = 7.38, df = 3, p = 0.061 |
Effects of treatment with single doses oral route of kaempferitrin (Km) at a 1, 5, 10 and 20 mg/kg and fluoxetine (FLX; 10 and 15 mg/kg; i.p.), desimipramine (DMI; 3.12, 6.25, 12.5 and 25 mg/kg, i.p.), and imipramine (IMI 6.25, 12.5, and 25 mg/kg) in the Forced Swimming Test (FST) in mice. All results are expressed as the average ± SEM of 8 to 12 animals. Comparisons were made using the Kruskal-Wallis analysis of variance based on rank, followed by the Mann-Whitney-U-test: * p < 0.05.