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. 2014 Dec 19;19(12):21442–21461. doi: 10.3390/molecules191221442

Table 1.

Effects of Km, FLX, DMI, and IMI on open field test activity.

Treatment (mg/kg) Ambulatory Activity (Count Number/5 min) Rearing Number/5 min
Control 31.7 ± 3.24 17.6 ± 1.46
Km1 35.0 ± 3.31 13.0 ± 3.40
Km5 29.0 ± 3.48 20.5 ± 3.90
Km10 32.1 ± 3.64 13.8 ±3.23
Km20 44.7 ± 0.2.29 * 17.7 ± 2.80
H = 10.72, df = 4, p = 0.030 H = 3.18, df = 4, p = 0.527
Control 41. 12 ±1.32 25.25 ± 3.63
FLX10 37.00 ± 2.17 21.75 ± 3.37
FLX 15 45.37 ± 3.13 28.12 ± 0.81
H = 5.39, df = 2, p = 0.067 H = 3.56, df = 2, p = 0.168
Control DMI 3.12 DMI 6.25 37.7 ± 3.24 35.50 ± 5.58 40.5 ± 6.33 29.3 ± 5.73 26.53 ± 3.82 26.8 ± 4.20
DMI 12.5 47.8 ± 3.92 28.0 ± 3.53
DMI25 40.1 ± 4.76 18.7 ± 5.26
H = 6.08, df = 4, p = 0.193 H = 4.97, df = 4, p = 0.06
Control 38.8 ± 1.29 25.2 ± 3.63
IMI 6.25 44.5 ± 6.04 36.5 ± 4.67
12.5 30.2 ± 4.43 27.5 ± 2.77
25 41.12 ± 6.18 34.5 ±7.72
H = 3.508, df = 3, p = 0.320 H = 7.38, df = 3, p = 0.061

Effects of treatment with single doses oral route of kaempferitrin (Km) at a 1, 5, 10 and 20 mg/kg and fluoxetine (FLX; 10 and 15 mg/kg; i.p.), desimipramine (DMI; 3.12, 6.25, 12.5 and 25 mg/kg, i.p.), and imipramine (IMI 6.25, 12.5, and 25 mg/kg) in the Forced Swimming Test (FST) in mice. All results are expressed as the average ± SEM of 8 to 12 animals. Comparisons were made using the Kruskal-Wallis analysis of variance based on rank, followed by the Mann-Whitney-U-test: * p < 0.05.