Scheme 2.
Synthesis of 2′-CH3-2′-F NAD (7).
Reagents and conditions: (a) LiAlH(OBut)3, THF; (b) PPh3, CBr4, DCM; (c) nicotinamide, MeCN, reflux; (d) K2CO3, MeOH, 3 h; (e) POCl3, TMP, 0 °C; (f) CDI, DMF, MeOH, AMP, rt, 3 days.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.