Scheme 4.
Synthesis of bis(ara-F NMN) (20), bis(ara-F NMN)[CH2] (21) and bis(2′-CH3- 2′-F NMN)[CH2] (22).
Reagents and conditions: (a) CDI, DMF, MeOH, rt, 3 days; (b) TMP, methylenebis(phosphonic dichloride), 0 °C, 5 h.
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