Table 1.

Summary of NAD analogues and their inhibitory activities of CD38 NADase. n.s. = no significant inhibitory effect was observed.

Modified Approach	Compd. No.	Compd. Name	IC50/nM
Control 1	23	Ara-F NAD	61.1
Control 2	8	Ara-F NMN	297
Nicotinamide nucleoside	7	2′-CH3-2′-F NAD	1.81 × 106
Pyrophosphate	10	S-ara-F NAD	341
	11	3P-ara-F NAD	1.15 × 103
Adenosine	12	Ara-F NHD	109
	13	Ara-F NGD	89.3
	19	6-OMe-ara-F NHD	133
Dimer	20	Bis(ara-F NMN)	575
	21	Bis(ara-F NMN)[CH2]	7.98 × 103
	22	Bis(2′-CH3-2′-F NMN)[CH2]	n.s.