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. 2014 Jul 31;19(8):11300–11315. doi: 10.3390/molecules190811300

Scheme 1.

General procedure of netropsin analogues syntheses.

Scheme 1

Reagents and conditions: (a) Aromatic nitroamine A-D, 12 h, DCM, rt; (b) 1 M SnCl2, 4 h DMF, rt; (c) 3-nitrobenzoyl chloride, 4-DMAP, DCM, 24 h, rt; (d) 1–6, DCM, 2 h 0 °C and rt, overnight; (e) TFA/DCM (95:5), 2 h, rt.