Figure 2.

Strategies to overcome the low bioavailability and solubility of curcumin. These strategies consist of the modification of the chemical structure of curcumin, in the combination of curcumin with adjuvants, in liposomal or micellar nano-formulations of curcumin and, more recently, in the design of hybrid molecules consisting of the conjugation of curcumin with an adjuvant, antibodies or other natural compounds.