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. 2014 Sep 29;19(10):15653–15672. doi: 10.3390/molecules191015653

Table 1.

Chemical structures of compounds 21–46 and their antifungal activities.

graphic file with name molecules-19-15653-i001.jpg

Compd. R1 R2 Ar Antifungal Activity MIC (μg/mL)
C. albicans ATCC 90028 C. albicans 205 C. albicans 64110 C. krusei ATCC 6528 C. tropicalis 657 C. Glabrata 923 C. Glabrata 186 C. parapsilosis 27
21 H 4-NO2 phenyl >128 >128 >128 >128 >128 8 16 >128
22 H 2-NO2 phenyl >128 >128 >128 >128 >128 >128 >128 >128
23 H 4-F phenyl 32 >128 >128 >128 >128 >128 >128 >128
24 H 4-Br phenyl 2 >128 >128 >128 >128 4 4 16
25 H 4-MeO phenyl >128 >128 >128 >128 >128 >128 >128 >128
26 H 2,4-diCl phenyl >128 >128 >128 >128 >128 >128 >128 >128
27 4,5-diCl 4-Br phenyl >128 >128 >128 >128 >128 >128 >128 >128
28 4-CH3 4-Br phenyl >128 >128 >128 >128 >128 >128 >128 >128
29 H 4-Br 4-Br-phenyl 8 >128 >128 >128 2 4 4 2
30 H 4-Br 4-Cl-phenyl 2 >128 >128 32 4 8 8 >128
31 H 4-Br 4-F-phenyl 0.5 4 8 8 2 2 2 4
32 H 4-Br 4-Me-phenyl 2 >128 >128 >128 >128 >128 >128 >128
33 H 4-Br 4-MeO-phenyl >128 >128 >128 >128 >128 >128 >128 >128
34 H 4-Br 4-CN-phenyl 2 >128 >128 >128 4 1 1 4
35 H 4-Br 2,4-diCl-phenyl 2 >128 >128 >128 2 >128 >128 4
36 H 4-Br 3,4-diF-phenyl 2 >128 >128 32 16 8 8 16
37 H 4-Br 3-Cl-4-F-phenyl >128 >128 >128 >128 >128 32 32 >128
38 H 4-Br 3-Br-4-F-phenyl >128 >128 >128 >128 >128 >128 >128 >128
39 H 4-Br 2,4-diF-phenyl 0.5 >128 64 64 16 32 32 8
40 H 4-Br 2-NO2-4-F-phenyl 8 >128 >128 >128 >128 >128 >128 >128
41 H 4-Br 1,1'-biphenyl >128 >128 >128 >128 >128 >128 >128 >128
42 H 4-Br pyridin-2-yl 4 8 8 32 2 4 8 8
43 H 4-Br 5-F-pyridin-2-yl 4 32 64 8 2 64 64 1
44 H 4-Br furan-2-yl >128 >128 >128 >128 >128 >128 >128 >128
45 graphic file with name molecules-19-15653-i002.jpg 8 128 128 128 128 128 128 32
46 graphic file with name molecules-19-15653-i003.jpg 0.25 64 128 16 8 32 32 8
Fluconazole 0.5 8 >128 32 16 32 32 1