Table 2.
Physicochemical properties of synthesized salts. LogP, polar and van der Waals surface areas and polarizability were calculated using MarvingSketch 6.0.2. RM values are presented as the mean ± SEM.
| Compound | mp (°C) | LogP | Polar surface area (Å2) | van der Waals surface area (Å2) | Polarizability | Hydrophobicity (RM) |
|---|---|---|---|---|---|---|
| 4a | >250 | −3.4 | 133.5 | 711.4 | 52.5 | 2.091 ± 0.027 |
| 4b | 241–243 | −3.6 | 60.3 | 730.7 | 53.6 | 2.325 ± 0.014 |
| 4c | >300 | −3.0 | 94.5 | 732.4 | 59.5 | 2.122 ± 0.047 |
| 4d | >300 | −3.2 | 68.2 | 707.4 | 57.6 | 1.938 ± 0.023 |
| 5a | 258–259 | −4.3 | 133.5 | 652.1 | 50.3 | 1.739 ± 0.035 |
| 5b | 252–253 | −4.5 | 60.3 | 667.1 | 51.6 | 2.142 ± 0.024 |
| 5c | >300 | −3.9 | 94.5 | 671.0 | 57.3 | 1.917 ± 0.049 |
| 5d | 301–302 | −4.1 | 68.2 | 646.0 | 55.4 | 2.092 ± 0.023 |