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Leishmanicidal activity of compounds 1–9, against Leishmania amazonensis.
| Compound | L. amazonensis | Macrophage cells (J774) | SI |
|---|---|---|---|
| IC50 (µg/mL) | CC50 (µg/mL) | ||
| 1 | 0.18 | 51.22 | 284.55 |
| 2 | >1000 | 96.56 | ND |
| 3 | 65.27 | 69.33 | 1.06 |
| 4 | >1000 | >1000 | ND |
| 5 | 48.17 | 47.66 | 0.98 |
| 6 | 71.53 | 58.97 | 0.82 |
| 7 | 39.53 | 59.97 | 1.52 |
| 8 | >1000 | >1000 | ND |
| 9 | >1000 | >1000 | ND |
| Amphotericin B | 0.20 | NT | NT |
SI: Selectivity Index = CC50 drug/IC50 drug; ND: Not determined; NT: not tested.
