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. 2014 May 22;19(5):6707–6726. doi: 10.3390/molecules19056707

Figure 7.

Figure 7

Effects of oligomers on object recognition memory deficit in SAMP8. Eighteen-week-old SAMP8 were administered vehicle (Veh, water p.o., n = 6) or oligomers (O (10), 10 mg/kg body weight/day, p.o., n = 6 or O (100), 100 mg/kg body weight/day, p.o., n = 5). Age-matched SAMR1 were used as a control (Cont, n = 5). Twenty-four days after the start of administration, a novel object recognition test was performed (A). Thirty-eight-week-old SAMP8 were administered vehicle (Veh, water p.o., n = 7) or oligomers (O (10), 10 mg/kg body weight/day, p.o., n = 7 or O (50), 50 mg/kg body weight/day, p.o., n = 7). Age-matched SAMR1 were used as a control (Cont, n = 7). Twenty-three days after the start of administration, a novel object recognition test was performed (B). The preference index was defined as the number of times a mouse made contact with any one of the objects (training session) or the novel object (test session) out of the total number of times the mouse made contact with both objects (%). * p < 0.05 (One-way ANOVA followed by Bonferroni’s post-hoc test); a p = 0.0174; b p = 0.0014 (paired t-test).