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. 2014 Feb 17;19(2):2061–2076. doi: 10.3390/molecules19022061

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© 2014 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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The effects of the solanidine analogs on mammalian DNA topoisomerase I activity. A representative agarose gel photograph of supercoil relaxation in the presence of 0.1 mM concentrations of the test substances. Lane 1, pBR322; lane 2, pBR322 with 1 u of DNA topoisomerase I; lane 3, same as lane 2 with DMSO, lanes 4 to 9, pBR322 with 1 u DNA topoisomerase I in the presence of 0.1 mM of 14, 12, 3, 1, 4 and 2, respectively.