Table 1.

Cytotoxic activities of ∆³-2-hydroxybakuchiol and its analogues against rat UMR106 osteosarcoma cell.

Entry	Comp.	Ar		R1	R2	IC50 (µM)
1	13a	4-MeO-C6H4		CO2Et	CH=CH2	27
2	13c	C6H5		CO2Et	CH=CH2	330
3	13d	4-Me-C6H4		CO2Et	CH=CH2	263
4	13e	2-C10H7		CO2Et	CH=CH2	>500
5	13f	4-CF3-C6H4		CO2Et	CH=CH2	242
6	13g	3,4-OCH2O-C6H4		CO2Et	CH=CH2	511
7	14a	4-MeO-C6H4		Me2CH(OH)	CH=CH2	66
8	14c	C6H5		Me2CH(OH)	CH=CH2	107
9	14d	4-Me-C6H4		Me2CH(OH)	CH=CH2	87
10	14e	2-C10H7		Me2CH(OH)	CH=CH2	128
11	14f	4-CF3-C6H4		Me2CH(OH)	CH=CH2	46
12	14g	3,4-OCH2O-C6H4		Me2CH(OH)	CH=CH2	115
13	14h	3-HO-C6H4		Me2CH(OH)	CH=CH2	123
14	14i	4-HO-C6H4		Et2CH(OH)	CH=CH2	57
15	14j	4-HO-C6H4		n-Bu2CH(OH)	CH=CH2	17
16	14b	4-HO-C6H4		Me2CH(OH)	CH2CH3	71
17	bakuchiol methyl ether (15c)					60
18	bakuchiol (15b)					62
19	ent-bakuchiol methyl ether (15e)					161
20	ent-bakuchiol (15d)					33
21	∆3-2-hydroxybakuchiol (15a)					69