Table 3.
The combined antimicrobial effect of antibiotics and berberine towards the reference CoNS staphylococci (mean inhibition growth zones in mm. Values are considered significant at p ≤ 0.05).
| Strain | P | P | E | E | DA | DA | FOX | FOX | CIP | CIP | TOB | TOB | C | C | LIN | LIN | TE | TE | SXT | SXT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| +be | +be | +be | +be | +be | +be | +be | +be | +be | +be | |||||||||||
| S. epidermidis ATCC35983 | 0 | 0 | 0 | 0 | 0 | 0 | 12 ± 2 | 18 ± 2 | 30 ± 2 | 32 ± 2 | 17 | 18 ± 2 | 23 ± 2 | 26 ± 2 | 30 ± 3 | 33 ± 1 | 27 ± 1 | 29 ± 1 | 29 ± 1 | 31 ± 1 |
| S. epidermidis ATCC12228 | 12 ± 2 | 22 ±1 | 27 ± 1 | 41 ± 1 | 27 ± 1 | 35 ± 1 | 34 ± 3 | 36 ± 2 | 28 ± 1 | 27 ± 1 | 27 ± 2 | 41 ± 1 | 28 ± 1 | 39 ± 1 | 33 ± 2 | 44 ± 2 | 0 | 9 ± 3 | 23 ± 2 | 23 ± 2 |
| S. haitalicolyticus ATCC29970 | 33 ± 1 | 46 ± 2 | 26 ± 2 | 35 ± 3 | 26 ± 1 | 37 ± 1 | 33 ± 1 | 47 ± 3 | 30 ± 1 | 39 ± 1 | 26 ± 1 | 40 ± 1 | 27 ± 1 | 41 ± 3 | 31 ± 2 | 45 ± 1 | 30 ± 1 | 48 ± 2 | 22 | 40 |
| S. hominis subsp. hominis ATCC27844 | 34 ± 2 | 38 ± 1 | 34 ± 2 | 40 | 29 ± 1 | 34 ± 2 | 32 | 41 ± 1 | 31 ± 2 | 33 ± 1 | 27 ± 1 | 30 ± 2 | 30 ± 2 | 35 ± 1 | 34 ± 3 | 45 ± 3 | 11 ± 1 | 12 ± 2 | 32 | 33 ± 1 |
| S. warneri ATCC49454 | 31 ± 2 | 31 ± 3 | 24 ± 2 | 26 ± 1 | 28 ± 2 | 28 | 32 | 37 ± 1 | 27 ± 1 | 30 ± 2 | 25 ± 1 | 26 | 26 ± 2 | 29 ± 3 | 31 ± 2 | 33 ± 2 | 31 ± 3 | 33 ± 1 | 31 ± 1 | 33 ± 2 |
| S. saprophyticus ATTC15303 | 27 ± 1 | 29 | 29 ± 1 | 32 ± 1 | 28 | 33 ± 1 | 31 ± 1 | 32 ± 1 | 27 ± 1 | 28 | 28 ± 1 | 32 ± 1 | 28 ± 2 | 29 ± 1 | 33 ± 2 | 36 ± 1 | 32 ± 2 | 37 ± 2 | 32 ± 2 | 33 ± 1 |
| S. capitis subsp. capitis ATCC35661 | 32 ± 3 | 35 ± 2 | 24 ± 1 | 31 ± 1 | 29 ± 1 | 31 ± 1 | 31 ± 1 | 36 ± 1 | 29 ± 1 | 32 ± 2 | 27 ± 1 | 33 ± 1 | 30 ± 1 | 38 ± 2 | 32 ± 2 | 37 ± 1 | 33 ± 2 | 37 ± 2 | 31 ± 2 | 36 ± 2 |
| S. intermedius ATCC29663 | 38 ± 2 | 42 ± 2 | 29 ± 1 | 35 ± 2 | 30 ± 3 | 32 ± 2 | 35 ± 1 | 37 ± 1 | 30 ± 2 | 31 ± 3 | 27 ± 1 | 29 ± 1 | 28 ± 1 | 31 ± 1 | 31 ± 1 | 34 ± 1 | 33 ± 1 | 36 ± 1 | 28 ± 1 | 32 ± 2 |
| S. lentus ATCC700403 | 24 ± 1 | 30 ± 3 | 25 ± 1 | 27 ± 1 | 22 ± 2 | 23 ± 1 | 34 | 39 ± 2 | 28 ± 2 | 27 ± 3 | 23 ± 3 | 25 ± 2 | 30 ± 1 | 30 ± 3 | 33 ± 1 | 35 ± 2 | 27 ± 2 | 31 ± 1 | 26 ± 2 | 28 ± 3 |
| S. lugdunensis ATCC49576 | 12 ± 1 | 15 ± 1 | 29 ± 1 | 33 ± 3 | 29 ± 2 | 33 ± 2 | 35 ± 2 | 38 ± 2 | 31 ± 3 | 34 ± 3 | 24 ± 2 | 30 ± 2 | 28 ± 2 | 29 ± 2 | 30 ± 1 | 33 ± 1 | 33 ± 1 | 37 ± 1 | 28 ± 2 | 30 ± 1 |
| S. simulans ATCC27851 | 19 ± 3 | 21 ± 3 | 31 ± 1 | 35 ± 1 | 31 ± 1 | 36 ± 3 | 36 ± 3 | 37 ± 2 | 36 | 37 ± 1 | 29 ± 2 | 31 ± 3 | 29 ± 1 | 33 ± 3 | 32 ± 1 | 36 ± 2 | 12 | 16 ± 1 | 28 ± 2 | 27 ± 1 |
| S. galinarium ATCC700401 | 9 | 13 ± 1 | 25 ± 1 | 33 ± 1 | 21 ± 1 | 27 ± 1 | 20 ± 1 | 27 ± 1 | 27 ± 1 | 30 ± 0 | 24 ± 1 | 30 ± 2 | 26 ± 1 | 31 ± 1 | 29 ± 1 | 34 ± 2 | 9 ± 1 | 11 ± 1 | 27 ± 1 | 27 ± 1 |
| S. sciuri ATCC29060 | 24 ± 1 | 27 ± 2 | 24 ± 1 | 27 | 24 ± 1 | 26 ± 1 | 28 | 32 ± 2 | 26 ± 1 | 26 ± 1 | 22 ± 1 | 24 ± 1 | 26 ± 1 | 29 ± 1 | 30 ± 1 | 33 ± 1 | 27 ± 1 | 31 ± 1 | 23 ± 1 | 23 ± 1 |
| S. xylosus ATCC700404 | 9 ± 2 | 12 ± 1 | 0 | 0 | 0 | 0 | 37 ± 1 | 39 ± 1 | 30 ± 1 | 30 ± 2 | 19 ± 1 | 20 ± 1 | 28 ± 2 | 30 ± 2 | 32 ± 1 | 35 ± 1 | 14 ± 1 | 16 ± 1 | 32 ± 2 | 32 ± 2 |
| average | 22 ± 1 | 26 ± 1 | 23 ± 1 | 28 ± 1 | 23 ± 1 | 27 ± 1 | 31 ± 1 | 36 ± 2 | 29 ± 1 | 31 ± 1 | 25 ± 1 | 29 ± 1 | 28 ± 1 | 32 ± 2 | 32 ± 2 | 37 ± 1 | 23 ± 1 | 27 ± 1 | 28 ± 1 | 31 ± 1 |