Figure 4. Phylofactorization of viruses by host range suggests a taxonomic-based surveillance prioritization scheme.

Clades identified by host-range phylofactorization vary in their fraction of zoonotic representatives, and inclusion of clades into model selection of trait-based analysis produces updated predictions for zoonosis in clades while controlling for other traits. Traits classifying the host-range clades suggest different pathways to spillover, from the vector-borne transmission of Togaviridae to environmental persistence of excreted Picornaviridae.