Table 1.
The main targeted treatments administered to dogs with tetanus (n indicates the number of dogs that received the treatment; days post‐onset refers to the number of days after the onset of clinical signs of tetanus that the treatment was performed)
| Treatment administered | Dogs with cpRBD | Dogs without cpRBD | Nonsurvivors | All survivors | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Median | Mean (SD) | Range (n) | Median | Mean (SD) | Range (n) | Median | Mean (SD) | Range (n) | Median | Mean (SD) | Range (n) | |
| Antibiotics (days administered) | ||||||||||||
| Metronidazole | 27.5 | 22.8 (8.2) | 10‐32 (22) | 31.5 | 42.3 (38.5) | 12‐94 (5) | 6.5 | 6.3 (3.0) | 2‐10 (7) | 18 | 22 (16.1) | 8‐94 (49) |
| Amoxicillin‐clavulanic acid | 22 | 20.1 (9.0) | 7‐32 (14) | 37 | 43.0 (34.0) | 10‐88 (5) | 1.5 | 3.5 (3.7) | 1‐10 (8) | 22 | 22.3 (18.2) | 4‐88 (29) |
| Penicillin G | 5.5 | 5.5 (6.1) | 1‐10 (2) | 0 | 0 | 0 (0) | 2 | 2 (0) | 2 (2) | 3 | 6.5 (7.8) | 1‐21 (8) |
| Muscle relaxants (days administered) | ||||||||||||
| Midazolam CRI | 6 | 6.6 (4.9) | 2‐13 (10) | Unknown | Unknown | Unknown (1) | 6.5 | 6.0 (1.4) | 4‐7 (4) | 6 | 6.6 (4.9) | 2‐13 (11) |
| Diazepam | 13 | 12.1 (10.5) | 2‐33 (10) | 12 | 13.3 (8.1) | 6‐22 (3) | 2 | 2 (0) | 2 (2) | 12 | 13.3 (11.2) | 2‐44 (21) |
| Methocarbamol | 23 | 22.5 (7.0) | 14‐30 (12) | 21.5 | 21.5 (10.6) | 14‐29 (2) | 3.5 | 3.5 (3.5) | 1‐6 (2) | 19 | 20.1 (7.5) | 10‐30 (17) |
| Anti‐toxin | ||||||||||||
| Dose (IU/kg) | 377 | 410.8 (292.1) | 100‐1000 (14) | 500 | 416.7 (144.3) | 250‐500 (4) | 100 | 131.0 (80.1) | 71‐222 (6) | 254 | 327.3 (256.1) | 17‐1000 (29) |
| Days post‐onset | 3 | 3.1 (1.7) | 1‐7 | 5 | 4.8 (2.1) | 2‐7 | 5 | 4.1 (1.9) | 2‐7 | 4 | 4.0 (2.0) | 1‐8 |
| Digit amputation/wound debridement | ||||||||||||
| Days post‐onset | 4.5 | 5.8 (3.1) | 4‐12 (10) | 6.5 | 6.5 (2.1) | 5‐8 (2) | 7.5 | 7.5 (0.7) | 7‐8 (2) | 6 | 6.1 (2.9) | 1‐12 (18) |
| Days after wound first noticed | 9.5 | 11.6 (3.7) | 8‐15 | 7.5 | 7.5 (10.6) | 0‐15 | 12 | 12 (0) | 12 | 12.5 | 11.9 (6.1) | 0‐26 |
| Feeding tube | ||||||||||||
| Days in place | 18 | 15 (6.9) | 7‐26 (15) | 7 | 11.3 (10.2) | 4‐23 (3) | 3.5 | 4 (2.1) | 2‐7 (7) | 12 | 14 (7.5) | 4‐27 (29) |
| Days placed post‐onset | 4 | 5.5 (3.0) | 1‐12 | 8 | 9 (3.6) | 6‐13 | 5 | 4.7 (2.3) | 2‐8 | 5 | 5.7 (2.9) | 2‐13 |
| Tracheostomy tube | ||||||||||||
| Days in place | 17.5 | 17.5 (0.7) | 17‐18 (2) | 0 | 0 | 0 (0) | 2.5 | 2.5 (0.7) | 2‐3 (3) | 12.5 | 12.3 (6.1) | 6‐18 (4) |
| Days placed post‐onset | 3 | 3 (0) | 3 | 0 | 0 | 0 | 7 | 7.0 (2.0) | 5‐9 | 3 | 3.75 (1.5) | 3‐6 |