Table 3.
Analysis time | Antibody | Subtype | Person-years | No. observed | No. expected | SIR (95% CI) | p-value |
---|---|---|---|---|---|---|---|
Overall risk | All | limited | 26624 | 24 | 18.9 | 1.27 (0.81–1.89) | 0.29 |
diffuse | 11062 | 6 | 6.6 | 0.91 (0.34–1.99) | 0.99 | ||
Cenp | limited | 11857 | 8 | 9.6 | 0.83 (0.36–1.63) | 0.75 | |
diffuse | 754 | 0 | 0.6 | 0.00 (0.00–6.27) | 0.99 | ||
Topo | limited | 4035 | 6 | 2.5 | 2.40 (0.88–5.23) | 0.084 | |
diffuse | 3134 | 2 | 1.7 | 1.19 (0.14–4.31) | 0.99 | ||
Pol III | limited | 962 | 3 | 0.7 | 4.31 (0.89–12.61) | 0.067 | |
diffuse | 2509 | 2 | 1.6 | 1.28 (0.15–4.62) | 0.93 | ||
CTP-Negative | limited | 4065 | 2 | 2.5 | 0.81 (0.10–2.91) | 0.99 | |
diffuse | 1709 | 0 | 0.9 | 0.00 (0.00–3.91) | 0.78 | ||
± 3 years | All | limited | 7935 | 5 | 3.9 | 1.27 (0.41–2.96) | 0.72 |
diffuse | 5210 | 2 | 2.7 | 0.75 (0.09–2.73) | 0.99 | ||
Cenp | limited | 3003 | 0 | 1.6 | 0.00 (0.00–2.28) | 0.40 | |
diffuse | 212 | 0 | 0.1 | 0.00 (0.00–35.12) | 0.99 | ||
Topo | limited | 1353 | 2 | 0.6 | 3.42 (0.41–12.34) | 0.23 | |
diffuse | 1393 | 1 | 0.6 | 1.69 (0.04–9.41) | 0.89 | ||
Pol III | limited | 305 | 2 | 0.2 | 10.43 (1.26–37.67) | 0.032 | |
diffuse | 1209 | 2 | 0.7 | 2.80 (0.34–10.11) | 0.32 | ||
CTP-Negative | limited | 1335 | 0 | 0.5 | 0.00 (0.00–6.88) | 0.99 | |
diffuse | 808 | 0 | 0.4 | 0.00 (0.00–10.48) | 0.99 |
Statistically significant p-value after adjustment for multiple (10) comparisons per analysis