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Diagram of the MAPK and PI3K pathways. The reported mutations in Langerhans cell histiocytosis (LCH) are indicated in red. The dotted arrow represents an effect that has not been fully evaluated. PIP1, phosphatidylinositol 3‐phosphate; PIP3, phosphatidylinositol‐3,4,5‐triphosphate; PTEN, phosphatase and tensin homolog deleted on chromosome 10; RTK receptor tyrosine kinase
