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. 2018 Nov 2;109(12):3910–3920. doi: 10.1111/cas.13824

Figure 4.

Figure 4

Methylation‐specific PCR (MSP) and breast cancer clinical outcome based on inactivation of Mieap‐regulated mitochondrial quality control (MQC). MSP analysis of the Mieap,NIX and BNIP3 promoters. Genomic DNA was extracted from surgically dissected invasive breast cancer and then treated with bisulfite treatment and subjected to MSP for Mieap/NIX/BNIP3 promoters. The results of MSP from 11 representative cases are shown. Mieap promoter methylation was detected in 6 cases. However, no samples showed NIX/BNIP3 methylation. M, methylated; U, unmethylated