Figure 1.

Silencing human epidermal growth factor receptor‐3 (HER3) reduces cell proliferation and clone formation ability with ionizing radiation (IR). sh‐Control, stably transduced with lentivirus vector; sh‐HER3, stably transduced with lentivirus‐mediated HER3 shRNA. A., Silencing HER3 by three different siRNAs in MCF‐7 and ZR75‐1 cells. HER3 protein was determined by western blot. B, Stable knockdown of HER3 was successfully established in both cells by shRNA. C, Cell proliferation was detected by CCK‐8 at different times. *P < .05, **P < .01. D, Survival curve was fitted according to the multitarget single‐hit model