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. 2015 Jan 27;20(2):2081–2099. doi: 10.3390/molecules20022081

Figure 3.

Figure 3

(A) In vitro autoradiogram of representative sections of human carotid plaques under baseline ([125I]MIP-1232) and blockade condition ([125I]MIP-1232 with excess unlabeled MIP-1232). Hematoxylin/eosin (HE) staining below represents plaque morphology. Scale bar 3 mm. (B) Quantified total and specific binding of [125I]MIP-1232 to normal arteries (n = 5), stable plaques (n = 16) and vulnerable plaques (n = 15) determined by autoradiography and corrected for tissue size. No significant intergroup differences were determined. Lines indicate mean values, diamonds indicate the specimens shown in A. (C) In vitro autoradiography with xenografts under baseline and blockade conditions. IHC staining for FAP of the SK-Mel-187 and the NCI-H69 xenograft (20 µm cryosections). Scale bar 3 mm for autoradiography; 50 µm for IHC images. Color scales for minimal to maximal binding.