Table 2.
Studies showing THC to be more active than curcumin.
| •THC was more active than curcumin in the carrageenin-induced rat paw edema test for anti-inflammatory activity [21] |
| •THC was more active than curcumin as an antioxidant [20,58,59,60,61] |
| •THC was more active than curcumin for suppression of lipid peroxidation of erythrocyte membrane ghosts [62]. |
| •THC was more active than curcumin for prevention of DMH-induced ACF formation in mice [63]. |
| •THC was more active than curcumin for suppression of radiation-induced lipid peroxidation [24]. |
| •THC was more active than curcumin for suppression of nitrilotriacetate-induced oxidative renal damage [64]. |
| •THC was more active than curcumin for suppression of LDL oxidation [65]. |
| •THC was more active than curcumin for inhibition of COX2-dependent arachidonic acid metabolism [27]. |
| •THC was equal to curcumin in potency for suppression of histamine release [46]. |
| •THC was more active than curcumin for inhibition of JNK activation [36]. |
| •THC was more active than curcumin for protection from chloroquine-induced hepatotoxicity in rats [66]. |
| •THC was more active than curcumin in normalizing blood glucose and improvement of altered carbohydrate metabolic enzymes in diabetic animals [67]. |
| •THC was more active than curcumin for antidiabetic effects in rats [59]. |
| •THC was more active than curcumin in increasing plasma insulin in diabetic rats [59,67,68] |
| •THC was more active than curcumin in preventing brain lipid peroxidation in diabetic rats [69]. |
| •THC was more active than curcumin in increasing tissue sialic acid [67]. |
| •THC was more active than curcumin for antidiabetic and antihyperlipidemic effects [70] |
| •THC was more active than curcumin in reducing accumulation and cross-linking of collagen in diabetic rats [71]. |
| THC was more active than curcumin in modulating renal and hepatic functional markers in diabetic rats [72] |
| •THC was more active than curcumin in modulating erythrocyte TBARS in diabetic rats [59]. |
| •THC was more active than curcumin in a hepatoprotective role in CCL4-induced liver damage in rats and alcoholic liver disease model rats [73]. |
| •THC was more effective than curcumin in improving the specific insulin binding to the receptors on erythrocytes [68]. |
| •THC was more active than curcumin in binding to phospholipase (PLA) 2 [74] |
| •THC was more active than curcumin in preventing azoxymethane-induced colon carcinogenesis [75]. |
| •THC was more active than curcumin as an antihypertensive [61]. |
| •THC activated p53 and p21 more effectively than curcumin [51]. |
DMH, 1, 2-dimethylhydrazine; ACF, aberrant crypt foci; LDL, low-density lipoprotein; COX2, cyclooxygenage-2; THC, tetrahydrocurcumin; JNK, c-Jun N-terminal kinases; TBARS, thiobarbituric acid reactive substances; CCl4, carbon tetrachloride