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. 2015 Feb 20;20(3):3582–3627. doi: 10.3390/molecules20033582

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© 2015 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Plot of MIC difference against (A) MSA; (B) PSA; (C) rel-PSA; (D) ClogP (E) ClogD_7.4 of barbituric acids along with tetramic acids in our previous reports [13,14,15,17]. The MIC difference is defined as MIC with 2.5% blood/ MIC without blood against S. pneumonia 9.