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. 2015 Apr 24;20(5):7586–7601. doi: 10.3390/molecules20057586

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© 2015 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Effects of dorsomorphin (A–F) and K02288 (G–L) on NO production and osterix expression. (A,B,G,H) Nitric oxide labelling by DAF-FM DA of 5 dpf Tg (osx:mcherry) larvae previously treated during 24 h with 100 µM dorsomorphin (B) or 20 µM K02288 (H) at 2 dpf. (C,D,I,J) mCherry red fluorescence of 5 dpf Tg (osx:mcherry) larvae previously treated during 24 h with 100 µM dorsomorphin (D) or 20 µM K02288 (H) at 2 dpf. Control embryos (A,C,G,I) were treated with DMSO. c: cleithrum; en: entopterygoid; o: operculum; p: parasphenoid. Scale bar: 200 µM. (E,F,K,L) Statistical analysis of replicate experiments investigating the effect of dorsomorphin (E, F) or K02288 (K,L) on nitric oxide (E,K) or mCherry (F, L) detection. *** indicates p-value < 0.005.

Effects of dorsomorphin (A–F) and K02288 (G–L) on NO production and osterix expression. (A,B,G,H) Nitric oxide labelling by DAF-FM DA of 5 dpf Tg (osx:mcherry) larvae previously treated during 24 h with 100 µM dorsomorphin (B) or 20 µM K02288 (H) at 2 dpf. (C,D,I,J) mCherry red fluorescence of 5 dpf Tg (osx:mcherry) larvae previously treated during 24 h with 100 µM dorsomorphin (D) or 20 µM K02288 (H) at 2 dpf. Control embryos (A,C,G,I) were treated with DMSO. c: cleithrum; en: entopterygoid; o: operculum; p: parasphenoid. Scale bar: 200 µM. (E,F,K,L) Statistical analysis of replicate experiments investigating the effect of dorsomorphin (E, F) or K02288 (K,L) on nitric oxide (E,K) or mCherry (F, L) detection. *** indicates p-value < 0.005.