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. 2015 Mar 31;20(4):5667–5679. doi: 10.3390/molecules20045667

Table 1.

Dual agents endowed with NO donating properties and selective hCA isoform inhibitory activity for the treatment of open-angle glaucoma.

Compound Structure Ki (nM)
hCA I hCA II hCA IV
Dorzolamide graphic file with name molecules-20-05667-i001.jpg 50,000 3.2 43
Isosorbide mononitrate graphic file with name molecules-20-05667-i002.jpg >100,000 >100,000 >100,000
1 graphic file with name molecules-20-05667-i003.jpg 2950 14 4360
2 graphic file with name molecules-20-05667-i004.jpg 470 71 46
3 graphic file with name molecules-20-05667-i005.jpg 410 13 181
4 graphic file with name molecules-20-05667-i006.jpg 705 76 339
5 graphic file with name molecules-20-05667-i007.jpg 1520 63 3905
6 graphic file with name molecules-20-05667-i008.jpg 189 18 44
7 graphic file with name molecules-20-05667-i009.jpg 242 198 345
8 graphic file with name molecules-20-05667-i010.jpg 15 10 47
9 graphic file with name molecules-20-05667-i011.jpg 40 28 154
10 graphic file with name molecules-20-05667-i012.jpg 137 33 225
11 graphic file with name molecules-20-05667-i013.jpg 32 10 46
12 graphic file with name molecules-20-05667-i014.jpg 43 14 38
13 graphic file with name molecules-20-05667-i015.jpg 395 101 139
14 graphic file with name molecules-20-05667-i016.jpg 587 88 148
15 graphic file with name molecules-20-05667-i017.jpg 41 12 76
16 graphic file with name molecules-20-05667-i018.jpg 950 71 89
17 graphic file with name molecules-20-05667-i019.jpg >100,000 >100,000 nd
18 graphic file with name molecules-20-05667-i020.jpg >100,000 >100,000 nd
19 graphic file with name molecules-20-05667-i021.jpg >100,000 >100,000 nd
20 graphic file with name molecules-20-05667-i022.jpg >100,000 >100,000 nd
21 graphic file with name molecules-20-05667-i023.jpg >100,000 >100,000 nd
22 graphic file with name molecules-20-05667-i024.jpg >100,000 >100,000 nd
23 graphic file with name molecules-20-05667-i025.jpg >100,000 >100,000 nd
24 graphic file with name molecules-20-05667-i026.jpg >100,000 >100,000 nd
25 graphic file with name molecules-20-05667-i027.jpg >100,000 >100,000 nd
26 graphic file with name molecules-20-05667-i028.jpg >100,000 >100,000 nd
27 graphic file with name molecules-20-05667-i029.jpg >100,000 >100,000 nd
28 graphic file with name molecules-20-05667-i030.jpg >100,000 >100,000 nd
Dichlorophenamide graphic file with name molecules-20-05667-i031.jpg 1200 38 15,000
Acetazolamide graphic file with name molecules-20-05667-i032.jpg 250 12 74

nd: not determined.