Scheme 4.
Synthesis of impurity 9. Conditions: (i) HCl, EtOH; (ii) 2, CDMT, NMM, DMF; (iii) (a) 4, CDMT, NMM, DMF; (b) pTsOH, EtOH; (iv) (a) 1 M NaOHaq, (b) 1 M HClaq
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