Scheme 5.
Synthesis of (S,S)-9 and (S,R)-9. Conditions: (i) (a) CbzCl, (b) 4, DIPEA, HATU, DMF (ii) (a) Pd/C, H2, EtOH; (b) 2, HATU; (iii) (a) 1 M NaOHaq, (b) 1 M HClaq.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.