Table 2.

Treatment regimens for H. pylori eradication in Asia [63,64,65,66].

Guidelines	First-Line Treatment	Second-Line Treatment
Second Asia Pasific Consensus 2009	Standard PPI-based triple therapy: 7–14 days •PPI, AMX 1 g, CAM 500 mg twice daily •PPI, MNZ 400 mg, CAM 500 mg twice daily •PPI, AMX 1 g, MNZ 400 mg twice daily Quadruple therapy: 7–14 days •PPI twice daily, BIS 240 mg twice daily, MNZ 400 mg, twice daily or three times daily, TCN 500 mg four times daily	Quadruple therapy: 7–14 days •PPI twice daily, BIS 240 mg twice daily, MNZ 400 mg, twice daily or three times daily, TCN 500 mg four times daily •LVX-based triple therapy: 10 daysPPI, LVX 250 mg (or 500 mg), AMX 1 g twice daily •Rifabutin-based triple therapy: 7–10 daysPPI, rifabutin 150 mg, AMX 1 g twice daily
Global Guidelines for developing countries	Triple therapy: 7 days •PPI + AMX + CAM/Furazolidone, twice daily Quadruple therapy(CAM resistance > 20%): 7–10 days •PPI twice daily +BIS + TCN +MNZ all four times daily Quadruple therapy(no known CAMresistance, BIS unavailable): 14 days •PPI + CAM + MNZ +AMX Sequential therapy: 10 days •PPI + AMX for 5 days followed by PPI + CAM and a nitroimidazole (tinidazole) for 5 day	Quadruple therapy •PPI + BIS + TCN + MNZ for 10–14 days •PPI + furazolidone + TCN + BIS for 10 days Triple therapy •PPI + furazolidone + LVX for 10 days •PPI + AMX + CAM for 7 days •PPI + AMX + LVX for 10 days
Japan 2013	Triple therapy: 7 days •AMX 750 mg, CAM 200mg (or 400 mg), and PPI twice daily	Triple therapy: 7 days •AMX 750 mg, MNZ 250mg, and PPI twice daily
China 2013	Triple therapy: 7–14 days •AMX 1 g (or MNZ 400 mg),CAM 500 mg, and PPI twice daily	Quadruple therapy: 10–14 days •BIS 220 mg, TCN 750 mg,MNZ 400 mg twice, and PPI twice daily for 10 or 14 days
Korea 2013	Triple therapy: 7–14 days •AMX 1 g, CAM 500 mg, and PPI twice daily	Quadruple therapy: 7–14 days •BIS 120 mg four times, TCN 500mg four times, MNZ 500 mg thrice, PPI twice daily for 7–14 days

Abbreviations: CAM: clarithomycin, MNZ: metronidazole, LVX: levofloxacin, AMX: amoxicillin, CIP: ciprofloxacin, TCN: tetracycline.