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. 2015 Jun 11;20(6):10800–10821. doi: 10.3390/molecules200610800

Table 8.

In vitro inhibition and selectivity index of truncated-rutaecarpines on AChE and BuChE [84,85].
graphic file with name molecules-20-10800-i022.jpg
Compound R AChE Inhibition (nM) a BuChE Inhibition (nM) b Selectivity Index c
5b [84] 83,380
physostigmine [84] 170 590 3.47
25a [85] H >10,000 >10,000
25b [85] graphic file with name molecules-20-10800-i023.jpg 326.6 3103 9.50
25c [85] graphic file with name molecules-20-10800-i024.jpg 147.9 10,160 68.70
25d [85] graphic file with name molecules-20-10800-i025.jpg 20.98 7322 349.17
tacrine [85] 222.7 29.98 0.1

The original data were given as mean +/− standard error of the mean (SEM), but intentionally omitted SEM for clarity. a 50% inhibitory concentration (means of at least 3 independent experiments) of eeAChE from electric eel; b 50% inhibitory concentration (means of at least 3 independent experiments) of eqBuChE from equine serum; c Selectivity Index for AChE = IC50 (BuChE)/IC50 (AChE).