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. 2015 Feb 25;20(3):3758–3775. doi: 10.3390/molecules20033758

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© 2015 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Proposed mechanisms of the cytoprotective effect of tyrosol on I/R-caused mortality in H9c2 cardiomyocytes. Tyrosol protect cardiomyocytes against I/R-caused mortality, at least partially, by inhibition of ROS accumulation, Hsp70-mediated prohibition of JNK and ERK signaling pathway and caspase-8 activation, and restoration of Bcl-2/Bax ratio.