Table 1.
Comparison of protein serum levels in DMD, BMD and female carriers (matched by age).
| Protein | DMD | BMD | Carriers | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Patients n = 19 Mean (±SD) |
Controls n = 21 Mean (±SD) |
p Value | Patients n = 4 Mean (±SD) |
Controls n = 4 Mean (±SD) |
p Value | Carriers n = 17 Mean (±SD)/Median (Range) |
Controls n = 17 Mean (±SD)/Median (Range) |
p Value | |
| MMP-9 | 502.021 (174.297) | 275.46 (68.62) | 0.012 * | 785.05 (180.9) | 165.3 (114.18) | 0.001 * | 590.48 (134.79) | 705.76 (155.62) | 0.244 |
| MMP-2 | 245.56 (37.69) | 255.60 (58.40) | 0.769 | 254.76 (32.98) | 519.83 (112.93) | 0.004 * | ND | ND | ND |
| FSTN | 1.39 (0.28) | 0.99 (0.14) | 0.008 * | 1.02 (0.152) | 0.715 (0.152) | 0.028 * | ¶ 0.992 (0.516–1.259) | ¶ 1.833 (0.934–2.702) | 0.008 * |
| GDF-8 | # 1.049 (0.364) | 3.22 (0.752) | ≤0.01 * | ND | ND | ND | 2.095 (0.726–4.354) | 2.886 (1.272–3.974) | 0.042 * |
| TIMP-1 | # 200.94 (22.3) | 199.15 (35.5) | 0.937 | ND | ND | ND | 239.5 (142.29–785.1) | 220.93 (124.7–448.7) | 0.558 |
Note: * stastistical significance, # n = 14, ¶ n = 9.