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. 2015 Jan 12;20(1):1104–1117. doi: 10.3390/molecules20011104

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© 2015 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Scheme 1 — Synthesis of the compounds 4a–4j. Reagents and conditions: (a) isobutyric acid, AgNO₃, (NH₄)₂S₂O₈, water, 80 °C; (b) CH₃MgI, Et₂O; (c) substituted benzaldehyde, pyridine, Et₂NH.