Table 1.

Antifungal activity of isopropyl derivatives 4a–4j and propyl derivatives 5a–5j (compared to fluconazole, voriconazole and terbinafine).

Compd.	MIC (μmol/L) IC80 or greater for yeasts and yeast-like organisms IC50 or greater for molds
	CA	CT	CK	CG	TA	AF	LC	TM
	24 h	24 h	24 h	24 h	24 h	24 h	24 h	72 h
	48 h	48 h	48 h	48 h	48 h	48 h	48 h	120 h
4a	˃125	˃125	˃125	˃125	˃125	˃125	˃125	˃125
	˃125	˃125	˃125	˃125	˃125	˃125	˃125	˃125
5a	˃500	˃500	˃500	˃500	˃500	500	500	7.81
	˃500	˃500	˃500	˃500	˃500	˃500	˃500	7.81
4b	62.5	125	˃250	125	125	62.5	125	15.62
	125	˃250	˃250	˃250	˃250	˃250	˃250	31.25
5b	62.5	62.5	˃125	62.5	62.5	31.25	˃125	15.62
	62.5	125	˃125	62.5	˃125	˃125	˃125	15.62
4c	62.5	˃250	˃250	˃250	˃250	62.5	˃250	62.5
	˃250	˃250	˃250	˃250	˃250	250	˃250	125
5c	˃500	˃500	˃500	˃500	˃500	˃500	˃500	31.25
	˃500	˃500	˃500	˃500	˃500	˃500	˃500	62.5
4d	˃250	˃250	˃250	˃250	˃250	˃250	˃250	˃250
	˃250	˃250	˃250	˃250	˃250	˃250	˃250	˃250
5d	˃125	˃125	˃125	˃125	˃125	˃125	˃125	˃125
	˃125	˃125	˃125	˃125	˃125	˃125	˃125	ND a
4e	˃125	˃125	˃125	˃125	˃125	˃125	˃125	31.25
	˃125	˃125	˃125	˃125	˃125	˃125	˃125	62.5
5e	500	˃500	˃500	˃500	˃500	500	˃500	500
	˃500	˃500	˃500	˃500	˃500	˃500	˃500	500
4f	250	˃500	250	˃500	˃500	˃500	˃500	125
	250	˃500	250	˃500	˃500	˃500	˃500	125
5f	˃125	˃125	˃125	˃125	˃125	˃125	˃125	˃125
	˃125	˃125	˃125	˃125	˃125	˃125	˃125	˃125
4g	32.15	˃250	˃250	˃250	˃250	125	125	7.81
	125	˃250	˃250	˃250	˃250	˃250	˃250	7.81
5g	˃500	˃500	˃500	˃500	˃500	˃500	˃500	250
	˃500	˃500	˃500	˃500	˃500	˃500	˃500	250
4h	NS b	NS b	NS b	NS b	NS b	NS b	NS b	NS b
	NS b	NS b	NS b	NS b	NS b	NS b	NS b	NS b
5h	15.62	62.5	32.15	125	˃250	62.5	˃250	7.81
	62.5	˃250	˃250	˃250	˃250	˃250	˃250	15.62
4i	7.81	˃250	˃250	˃250	˃250	125	250	3.90
	62.5	˃250	˃250	˃250	˃250	˃250	250	7.81
5i	˃62.5	˃62.5	˃62.5	˃62.5	˃62.5	˃62.5	˃62.5	7.81
	˃62.5	˃62.5	˃62.5	˃62.5	˃62.5	˃62.5	˃62.5	15.62
4j	˃125	˃125	˃125	˃125	˃125	˃125	˃125	≤62.5
	˃125	˃125	˃125	˃125	˃125	˃125	˃125	≤62.5
5j	>62.5	>62.5	>62.5	>62.5	>62.5	>62.5	>62.5	7.81
	>62.5	>62.5	>62.5	>62.5	>62.5	>62.5	>62.5	7.81
FLU	0.24	˃500	125	41.64	250	˃500	˃500	6.51
	0.24	˃500	250	250	500	˃500	˃500	104
VOR	0.005	125	0.65	83.58	3.26	0.49	208	0.08
	0.007	250	1.95	250	14.32	1.3	250	0.12
TER	˃6.86 c	˃6.86 c	˃6.86 c	˃6.86 c	NA d	NA d	NA d	0.01–1.72 c

Notes: CA = Candida albicans ATCC 44859, CT = Candida tropicalis 156, CK = Candida krusei E 28, CG = Candida glabrata 20/I, TA = Trichosporon asahii 1188, AF = Aspergillus fumigatus 231, LC = Lichtheimia corymbifera (formerly Absidia corymbifera [48]) 272, TM = Trichophyton mentagrophytes 445; FLU = fluconazole, VOR = voriconazole, TER = terbinafine; ^a: not determined, ^b: not soluble, ^c: IC₅₀ after 7 days of incubation [49], ^d: not available.