Table 1.

Physical data, AChE and BChE inhibitory activities of 4a–j.

Entry	Comp 4	R	Yield (%) a	mp °C	AChE Inhibition IC50 µM (±SD)	BChE Inhibition IC50 µM (±SD)
1	a	H	85	134–135	11.29 ± 0.21	15.73 ± 0.22
2	b	2-CH3	87	141–142	10.15 ± 0.17	21.32 ± 0.19
3	c	2-OCH3	82	126–127	12.23 ± 0.19	11.39 ± 0.12
4	d	2-Cl	85	136–137	15.17 ± 0.22	9.63 ± 0.15
5	e	3-OCH3	84	127–128	2.13 ± 0.11	17.44 ± 0.23
6	f	3-O2N	89	133–134	1.57 ± 0.09	15.32 ± 0.18
7	g	4-CH3	92	138–139	7.11 ± 0.13	10.46 ± 0.24
8	h	4-OCH3	80	129–130	3.67 ± 0.15	14.69 ± 0.17
9	i	4-Cl	88	132–133	5.83 ± 0.20	16.11 ± 0.15
10	j	2,4-Cl2	90	135–136	6.72 ± 0.18	12.79 ± 0.25
11	Galantamine	-	-	-	2.09 ± 0.07	19.21 ± 0.12
12	Donepezil	-	-	-	0.21 ± 0.02	3.6 ± 0.11

^a Isolated yield.