Table 3.
Isoalantolactone and alantolactone concentration (ng/g) 1–48 h after oral administration in rats (n = 6).
| Concentration (ng/g) | |||||||
|---|---|---|---|---|---|---|---|
| 1.0 h | 3.0 h | 5.0 h | 8.0 h | 12.0 h | 24 h | 48 h | |
| Heart | |||||||
| Isoalantolactone | 10.1 ± 0.3 a | 44.6 ± 9.5 | 21.1 ± 6.5 | 11.1 ± 1.0 | 7.2 ± 0.8 | - | - |
| Alantolactone | 6.1 ± 1.0 | 31.0 ± 16.7 | 10.2 ± 2.2 | 6.9 ± 0.9 | 6.4 ± 0.3 | - | - |
| Spleen | |||||||
| Isoalantolactone | 17.9 ± 7.1 | 18.3 ± 8.1 | 8.6 ± 4.2 | 4.4 ± 1.5 | - | - | - |
| Alantolactone | 14.8 ± 3.1 | 20.0 ± 5.9 | 13.1 ± 2.4 | - | - | - | - |
| Lung | |||||||
| Isoalantolactone | 26.8 ± 11.5 | 83.2 ± 38.1 | 21.8 ± 9.2 | - | - | - | - |
| Alantolactone | 26.0 ± 10.7 | 92.1 ± 45.2 | 33.9 ± 5.8 | - | - | - | - |
| Kidney | |||||||
| Isoalantolactone | 78.6 ± 20.7 | 96.9 ± 9.9 | 92.9 ± 11.4 | 51.4 ± 6.3 | 49.8 ± 5.1 | 10.3 ± 4.1 | - |
| Alantolactone | 50.8 ± 8.8 | 66.6 ± 8.7 | 49.2 ± 8.3 | 35.6 ± 4.9 | 31.1 ± 4.9 | - | - |
| Liver | |||||||
| Isoalantolactone | 170.1 ± 23.8 | 311.3 ± 113.5 | 243.5 ± 149.4 | 182.0 ± 33.8 | 124.3 ± 23.3 | 20.2 ± 9.8 | - |
| Alantolactone | 254.6 ± 24.3 | 341.0 ± 24.9 | 301.8 ± 69.0 | 205.4 ± 36.0 | 167.6 ± 34.5 | 20.9 ± 6.9 | - |
| Stomach | |||||||
| Isoalantolactone | 1779.7 ± 406.6 | 376.5 ± 83.6 | 219.6 ± 57.8 | 59.4 ± 27.3 | - | - | - |
| Alantolactone | 1792.7 ± 576.8 | 302.0 ± 45.3 | 210.3 ± 52.0 | 36.7 ± 11.6 | - | - | - |
| Small intestine | |||||||
| Isoalantolactone | 1656.9 ± 821.6 | 2461.5 ± 263.7 | 1559.6 ± 478.1 | 614.2 ± 225.4 | 45.4 ± 9.4 | - | - |
| Alantolactone | 1222.1 ± 377.5 | 3118.0 ± 389.8 | 2033.7 ± 548.0 | 947.1 ± 420.8 | - | - | - |
| Colon | |||||||
| Isoalantolactone | 21.2 ± 2.9 | 116.4 ± 31.2 | 147.5 ± 74.7 | 486.7 ± 267.1 | 455.7 ± 223.9 | 100.6 ± 27.3 | - |
| Alantolactone | 15.6 ± 5.0 | 167.3 ± 56.5 | 187.1 ± 89.1 | 662.0 ± 273.8 | 502.1 ± 164.2 | 105.2 ± 31.8 | - |
a Mean ± SD.