Table 4.
Excretion of lactones in rats urine after a single oral administration at 90 mg/kg.
| Rat Number | Time (h) | |||||||
|---|---|---|---|---|---|---|---|---|
| 0–1 | 1–3 | 3–5 | 5–8 | 8–12 | 12–24 | 24–48 | Total (ng) | |
| 1 | ||||||||
| Isoalantolactone | - | - | 92.0 | 106.8 | 154.8 | 58.8 | 4.8 | 325.1 |
| Alantolactone | - | - | 38.1 | 32.6 | 108.4 | - | - | 179.0 |
| 2 | ||||||||
| Isoalantolactone | - | 639.1 | 23.2 | 29.2 | 51.9 | - | - | 743.3 |
| Alantolactone | - | 250.6 | 13.0 | - | 38.5 | - | - | 301.9 |
| 3 | ||||||||
| Isoalantolactone | - | 28.0 | - | 102.8 | 56.3 | - | - | 187.1 |
| Alantolactone | - | - | - | 43.2 | 13.5 | - | - | 56.7 |
| 4 | ||||||||
| Isoalantolactone | 32.1 | 115.0 | - | 15.0 | 41.4 | 31.6 | - | 235.2 |
| Alantolactone | - | 129.3 | - | 21.4 | 18.7 | - | 169.3 | |
| 5 | ||||||||
| Isoalantolactone | - | 6.2 | - | - | 104.3 | - | - | 110.5 |
| Alantolactone | - | - | - | - | - | 49.6 | - | 49.6 |
| 6 | ||||||||
| Isoalantolactone | - | - | 510.0 | 554.1 | - | - | - | 1219.0 |
| Alantolactone | - | - | - | 149.7 | 270.2 | - | - | 419.9 |