Table 5.

Excretion of lactones in rats bile after a single oral administration at 90 mg/kg.

Time (h)	Isoalantolactone (μg)	Alantolactone (μg)
0–1	4.3 ± 2.8 a	4.6 ± 0.7
1–3	12.1 ± 1.1	16.9 ± 1.2
3–5	18.8 ± 5.6	19.3 ± 10.0
5–8	51.4 ± 9.1	61.9 ± 19.2
8–12	77.8 ± 9.7	39.0 ± 7.9
12–15	58.3 ± 12.7	34.6 ± 8.9
15–24	149.9 ± 57.5	69.9 ± 36.8
24–48	81.3 ± 30.3	23.7 ± 4.9
48–72	-	-
Total	453.8	269.8

^a Mean ± SD.