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. 2015 May 27;20(6):9816–9846. doi: 10.3390/molecules20069816

Figure 1.

Figure 1

Structure of N-linked oligosaccharides. The pre-formed oligosaccharide covalently attached to Asn-Xxx-Ser/Thr sequences of nascent polypeptide chains is composed of three glucoses (grey triangles), nine mannoses (green and orange circles) and two N-acetylglucosamines (blue squares). Mannose residues that are removed by members of the glycosyl hydrolase family 47 (ER mannosidase I (ERManI) or EDEM1, EDEM2, EDEM3) are marked as green circles. It should be noted that extensive trimming of these mannoses by ERManI and/or Golgi endomannosidases was also reported (see text). Glucose n is removed by glucosidase I (GI), glucose residues m and l are both removed by glucosidase II (GII). A, B and C define the oligosaccharide branch. Letters a–n specify particular sugar residues. These letters are used throughout the text. The type of glycosidic bond is shown in color.