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. 2015 Mar 2;20(3):3868–3897. doi: 10.3390/molecules20033868

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© 2015 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Scheme 8 — Outline of the synthesis of 10. AT₁R affinity assay was determined using rat liver membrane, while porcine myometrial membrane was used for AT₂R. [¹²⁵I]Ang II was used as radioligand (0.03 nM).