. 2015 May 25;20(6):9496–9509. doi: 10.3390/molecules20069496

Table 3.

Pharmacokinetic parameters of sirolimus-loaded solid dispersions in rats.

Formulation	AUC_{0→12 h} (ng·h/mL)	C_max (ng/mL)	T_max (h)
Physical mixture (sirolimus/E-SD/TPGS = 1/8/1)	64.0 ± 11.8	9.6 ± 2.6	3.8 ± 1.1
Solid dispersion (sirolimus/E-SD/TPGS = 1/8/1)	459.5 ± 93.6 ^a,b	97.4 ± 19.2 ^a,b	1.2 ± 0.3
Solid dispersion (sirolimus/HPMC/TPGS = 1/8/1)	325.5 ± 46.4 ^a	61.0 ± 14.2 ^a	1.6 ± 0.5

^a p < 0.05 vs. physical mixture; ^b p < 0.05 vs. sirolimus/HPMC/TPGS. Data are expressed as the mean ± standard deviation (n = 5).